Maintenance – The GLP-1 Lab

How to restart a GLP-1 after a break

Ask your prescriber first. After 2 or more missed weekly Wegovy doses, the label says to restart the dose build-up at a lower dose to spare your gut.

Stopping, breaks & restarting

Stopping a GLP-1 before surgery: how long and why

Not always. Since 2024, guidance says many people can stay on a GLP-1 before surgery; if held, it is 1 week for weekly shots, the day of for daily pills.

Compounded semaglutide & tirzepatide

Compounded semaglutide vs Ozempic and Wegovy: what’s actually different

Same molecule on paper, different rules: compounded semaglutide is not FDA approved, may use salt forms, comes in vials and lost shortage cover in 2025.

Life situations

Getting colds or getting sick more often on a GLP-1?

Adult labels do not list colds or a weaker immune system. Eating far less, short sleep and the season are likelier causes. Protein, sleep and fluids help.

Cost, insurance & access

GLP-1 shortage: what to do when the pharmacy is out

The national semaglutide and tirzepatide shortages ended in 2024 and 2025. A local stock-out is usually brief: call other pharmacies, then your prescriber.

Life situations

GLP-1 and sick days: flu, stomach bug, antibiotics

Fluids first: vomiting or diarrhea on a GLP-1 can strain the kidneys. Ask your prescriber before skipping a dose, and space minerals from antibiotics.

Mood & mental health

Does a GLP-1 cause depression or mood changes?

FDA reviewed 91 trials in 2026 and found no increased risk of depression or suicidal thoughts. Mood can still dip; report any change. Crisis: call 988.

Cost, insurance & access

GLP-1 savings cards, coupons and manufacturer programs

As of October 2026, maker savings cards cut copays to as little as $25 with commercial insurance that covers the drug. Medicare and Medicaid are excluded.

Injection day & dosing

Missed a GLP-1 dose: what to do

Ozempic: take it within 5 days, else skip. Wegovy: take it if the next shot is 2+ days away. Zepbound, Mounjaro: 4 days. Daily pills: skip. Never double.